Nicholas James, MBBS, PhD, FRCP, FRCR, The Royal Marsden NHS Foundation Trust, London, UK, comments on key trials that will be presented in the field of prostate cancer at this year’s European Society for Medical Oncology (ESMO) 2022, including the Phase III RADICALS trial (NCT00541047). The study aims to assess the administration of adjuvant radiotherapy in patients with relapsed prostate cancer, as well as the role of hormone therapy in this group of patients. This interview took place at the European Society for Medical Oncology (ESMO) 2022 Congress in Paris, France.