Nicholas James, MBBS, PhD, FRCP, FRCR, The Institute of Cancer Research, London, UK, gives his prostate cancer highlights of the 2020 Genitourinary Cancers Symposium, held in San Francisco, CA. These include UK data from the CHHiP (NCT00392535) and STAMPEDE (NCT00268476) trials, as well as new developments in molecular sub-typing that will allow more personalized patient care.