Maha Hussain, MBChB, FACP, FASCO, of Northwestern University Feinberg School of Medicine, Chicago, IL, presents the results of the phase 3 PROfound study of olaparib vs. enzalutamide or abiraterone for metastatic castration-resistant prostate cancer HRR gene alterations. Next, Ignacio Duran, MD, PhD, Marques de Valdecilla University Hospital, Santander, Spain, discussing the impact of these data.