ESMO Sarcoma and Rare Cancers 2023 | Unmet needs and precision oncology advancements in metastatic GIST

Robin Jones, MBBS, MRCP, MD, The Royal Marsden Hospital, London, UK, discusses the need for continuous drug development and clinical evaluation of tyrosine-kinase inhibitors (TKI) in the context of metastatic gastrointestinal stromal tumors (GIST). As TKI resistance is a common occurence in patients with advanced GIST, Prof Jones highlights that drugs such as avapritinib have demonstrated impressive response rates in tumors that harbor the PDGFRαD842 mutation and are therefore resistant to TKIs such as Imatinib. This interview took place at the ESMO Sarcoma and Rare Cancers Congress 2023 in Lugano, Switzerland.

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