Alison Birtle, MD, of Royal Preston Hospital Lancashire Teaching Hospitals, Preston, UK, discusses the sequencing of drugs in metastatic castration-resistant prostate cancer. Excitingly, the first prospective study to assess sequencing in this disease space (NCT02254785) was presented on the first day of at the European Society for Medical Oncology (ESMO) 2018 Congress, in Munich, Germany (Kim Chi, et al.). Dr Birtle discusses the sequencing of cabazitaxel, abiraterone or enzalutamide in this study, and highlights the promising data that was reported for the study endpoints.