ASCO GI 2024 | EMERALD-1 trial: improved PFS w/ durvalumab + bevacizumab + TACE vs TACE in hepatocellular carcinoma

Lorenza Rimassa, MD, IRCCS Humanitas Research Hospital Rozzano, Milan, Italy, discusses the Phase III EMERALD-1 (NCT03778957) trial evaluating the combination of durvalumab (D) and bevacizumab (B) with transarterial chemoembolization (TACE) in unresectable hepatocellular carcinoma (uHCC). In this double-blind trial, participants were randomized to receive D+B+TACE, D+TACE, or TACE alone. The primary endpoint, progression-free survival (PFS), significantly improved for D+B+TACE compared to TACE alone (median PFS 15.0 vs. 8.2 months). The safety profile was manageable. D+B+TACE has the potential to become a new standard of care for uHCC. This interview took place at the 2024 ASCO Gastrointestinal (GI) Cancers Symposium in San Francisco, CA.

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