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ESMO 2026 | Further molecular profiling of patients with CDC and RMC in the REPRINT trial

Giuseppe Procopio, MD, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy, comments on ongoing investigations into biological samples collected in the Phase II REPRINT trial (NCT06302569) to identify genomic features that can help select patients with collecting duct carcinoma (CDC) and renal medullary carcinoma (CMC) for treatment. SMARCC2B1 deficiency is a lost tumor suppressor gene and a potential candidate for treatment. This interview took place at the European Society for Medical Oncology (ESMO) 2026 Congress in Madrid, Spain.

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