ASCO GI 2023 | microRNAs as a biomarker of resistance to trastuzumab in GEC

Hazel Lote, PhD, Institute of Cancer Research, Sutton, UK, discusses findings from a sub-study of the Phase II PLATFORM trial (NCT02678182) analyzing microRNAs as potential biomarkers of resistance to trastuzumab in patients with esophago-gastric cancer (GEC). Previous studies have determined high miR-148a-3p levels to negatively impact progression-free survival (PFS) and overall survival (OS). Whilst miR-148a-3p levels were not linked to PFS and OS in the sub-analysis, it was linked to 3-month
progression-free rates post- trastuzumab. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.

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