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Hisham Mehanna, PhD, BMedSc, MBChB, FRCS, FRCS(ORL-HNS), of the University of Birmingham, Birmingham, UK, speaks from the European Society for Medical Oncology (ESMO) 2018 Congress, in Munich, Germany, discussing recent changes to the old staging system for HPV-positive cancer patients. Changes to clinical staging and pathological staging are explained.