ESMO Asia 2023 | Tyrosine kinase inhibitors in EGFR-mutant NSCLC: when and who?

Masahiro Tsuboi, MD, National Cancer Center Hospital East, Chiba, Japan, discusses when and to whom to administer tyrosine kinase inhibitor (TKI) treatment. The NEJ009 study (NCT04035486) showed getfitinib plus chemotherapy prolonged survival and improved overall response rate in comparison to getfitinib alone. Likewise, FLAURA-2 (NCT04035486) has shown osimertinib to be more efficacious when administered with chemotherapy. Testing osimertinib specifically in the neoadjuvant setting, Dr Tsuboi is eager for the results of Neo-ADAURA (NCT04351555) to further the understanding of TKI and chemotherapy’s temporal relationship. Dr Tsuboi addresses patient selection and states liquid biopsy could be of use in identifying patients who could benefit. This interview took place at the European Society for Medical Oncology (ESMO) Asia 2023 Congress in Singapore.

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