Ghassan K. Abou-Alfa, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses the role of molecular testing in the development of cost-effective targeted therapies. Prof. Abou-Alfa highlights the importance of mass next-generation sequencing (NGS) and discusses novel approaches which aim to circumvent the operational and financial limitations currently associated with it. This interview took place at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.