Saverio Alberti, MD, PhD, of the Università degli Studi di Messina, Italy, discusses the role of E-cadherin and Trop-2 in epithelial-mesenchymal (EMT)-less metastasis, and the impact of this interaction in cancer cell metastasis, suggesting a prognostic role for likelihood of malignancies in these markers as well as potential targets for treatment. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).