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GU Cancers 2026 | ULTRA-HERO: radiotherapy & relugolix for intermediate risk prostate cancer

Giulio Francolini, MD, University of Florence, Florence, Italy, provides an overview of the ULTRA-HERO trial design, a prospective Phase II study investigating ultra-hypofractionated radiotherapy combined with short-course oral relugolix for unfavorable intermediate-risk prostate cancer. This approach aims to maintain disease control comparable to standard androgen deprivation therapy while reducing long-term toxicities through the rapid testosterone recovery associated with the gonadotropin-releasing hormone antagonist. This interview took place at the 2026 ASCO GU Cancers Symposium in San Francisco, CA.

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Transcript

This is a trial that we are currently running in Italy. It’s 14 institutions running a multi-centred trial in which we are treating patients with ultra-hypofractionated radiotherapy on prostate cancer for intermediate and several prostate cancer disease and concomitant relugolix administration. And the relugolix is given in a short course ADT schedule, meaning that all patients were given six months of ADT...

This is a trial that we are currently running in Italy. It’s 14 institutions running a multi-centred trial in which we are treating patients with ultra-hypofractionated radiotherapy on prostate cancer for intermediate and several prostate cancer disease and concomitant relugolix administration. And the relugolix is given in a short course ADT schedule, meaning that all patients were given six months of ADT. And it will be very interesting to see if a higher rate of early testosterone recovery after the end of ADT will come with the same oncological benefits as standard concomitant ADT plus radiotherapy. We have currently enrolled 20 patients but we plan to end the enrollment by the end of 2027.

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