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SABCS 2022 | TAM-01: low-dose tamoxifen in women with breast intraepithelial neoplasia

Andrea De Censi, MD, PhD, National Hospital E.O. Ospedali Galliera – S.C. Oncologia Medica, Genoa, Italy, provides an overview of the Phase III TAM-01 (NCT01357772) clinical trial investigating low-dose tamoxifen versus placebo in patients with breast intraepithelial neoplasia, which includes woman with invasive breast cancer and ductal carcinoma in situ (DCIS). A previous biomarker trial had demonstrated a lower dose of tamoxifen was non-inferior to the standard dose but associated with fewer side-effects, providing the rationale for this clinical trial. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.

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