Gayathri Anandappa, MBBS, MRCP, MPhil, from The Royal Marsden NHS Foundation Trust, London, UK, explains the importance of a personalized approach to the management of patients with colorectal cancer (CRC) and describes some of the key challenges that still need to be addressed. Dr. Anandappa also describes the potential impact that technologies such as liquid biopsy and the Immunoscore assay may have on CRC management. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).