Natasha Leighl, BSc, MMSc, MD, Cancer Clinical Research Unit, Princess Margaret Cancer Centre, Toronto, Canada, discusses the challenge of brain metastases in ALK+ non-small cell lung cancer (NSCLC). She highlights the importance of early treatment with agents that reduce this progression; however, she explains how this leaves fewer options for subsequent lines of treatment. This interview took place at the 18th British Thoracic Oncology Group (BTOG) 2020 congress held in Dublin, UK.