Sujay A. Vora, MD, Mayo Clinic, Phoenix, AZ, discusses the results of a Phase II (NCT03778294) trial investigating short course hypofractionated proton beam therapy incorporating 18F-DOPA-PET/MRI for elderly patients with newly diagnosed glioblastoma, which demonstrated improved overall-survival (OS) and progression-free survival (PFS) for all patients. Further improvement was shown in patients with MGMT methylation. Future directions within this line of research include an upcoming trial with a larger group of patients randomizing patients to short course hypofractionated proton beam therapy incorporating 18F-DOPA-PET/MRI versus the standard of care radiation over 3-6 weeks with standard radiation photon-based treatment. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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