Giuseppe Curigliano, MD, PhD, University of Milan, Milan, Italy, discusses highlights from the virtual 17th St. Gallen International Breast Cancer Consensus session on the optimal treatment of women with early breast cancer, including conversations on the use of pathological complete response as a surrogate marker for long-term outcomes, the role of gene signatures in stratifying risk in the adjuvant setting as well as the use of carboplatin in the neoadjuvant setting. This interview took place during the 17th St. Gallen International Breast Cancer Conference.