Shubham Pant, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the implementation of precision medicines for biliary tract cancer. Targeted therapies are approved for intrahepatic cholangiocarcinoma (CCA) targeting FGFR fusions and alterations which are significantly enriched in intrahepatic CCA, including pemigatinib and futibatinib, as well as ivosidenib for targeting IDH1. Additionally, agents are currently in development for HER2 overamplification, which is mostly seen in gallbladder cancer and extrahepatic cholangiocarcinoma. The scope of genomic aberrations o identified in biliary tract cancer highlights the importance of genomic testing in this patient population with next-generation sequencing (NGS) to take advantage of the targeted therapies available. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.
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