Meredith M. Regan, ScD, Harvard Medical School, Boston, MA, discusses what trials she is looking forward to in the field of pre- and post-menopausal hormone receptor-positive early breast cancer at SABCS 2021. Trials being presented at the congress include SOFT (NCT00066690), TEXT (NCT00066703), HOBOE (NCT00412022) and RxPONDER (NCT01272037). This interview took place at the San Antonio Breast Cancer Symposium 2021 in San Antonio.