Sébastien Perreault, MD, FRCPC, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada, reflects on the use of targeted therapies in central nervous system (CNS) tumors, including targeting of the MAP kinase pathways which are prevalent in this patient population, the use of oral agents as well as addressing how long to continue treatment. This interview took place at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.