Philippe Merle, MD, PhD, Croix-Rousse Hospital, Lyon, France, discusses the future directions in the treatment of hepatocellular carcinoma, including safe and efficacious therapies, combinatorial approaches and personalized medicine. Prof. Merle also highlights biomarkers as an urgent area of unmet need in patients with HCC. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).