ASCO GI 2024 | NIVO + chemo vs chemo as 1L treatment for advanced GC/GEJC/EAC: 4 year yr follow-up of CheckMate 649

Kohei Shitara, MD, National Cancer Center Hospital East, Kashiwa, Japan, presents the 4-year follow-up results of the Phase III CheckMate 649 (NCT02872116) trial, evaluating nivolumab in combination with chemotherapy (chemo) versus chemo alone in previously untreated, advanced non-HER2+ gastric cancer/gastroesophageal junction/esophageal adenocarcinoma (GC/GEJC/EAC). The study, which demonstrated superior overall survival (OS) and progression-free survival (PFS) benefits with nivolumab + chemo, continues to show efficacy in patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) ≥ 5. nivolumab + chemo maintains a favorable safety profile, making it the first PD-1 inhibitor/chemo combination to exhibit long-term efficacy and safety after 4 years in this patient population. This interview occurred at the 2024 ASCO Gastrointestinal (GI) Cancers Symposium in San Francisco, CA.

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