Tobias Maurer, MD, University Medical Center Hamburg-Eppendorf, Hamburg, Germany discusses evidence highlighting the superiority of PSMA-PET to conventional imaging techniques and the benefits of using PSMA-PET for the upfront staging of prostate cancer in high-risk patients. Specifically, Dr Maurer describes how PSMA-PET is particularly beneficial in staging certain subgroups of high-risk prostate cancer patients, such as those lacking elevated prostate-specific antigen (PSA) levels. This interview took place at the European Association of Urology (EAU) Meeting 2022.