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ASCO GI 2024 | MATTERHORN: improved pCR with the use of durvalumab + FLOT in resectable GC/GEJC

Yelena Y. Janjigian, MD, Memorial Sloan Kettering Cancer Center, New York, NY, provides an overview of the MATTERHORN study (NCT04592913), which aimed to enhance perioperative therapy for resectable gastric/gastroesophageal junction cancer (GC/GEJC). Randomizing participants to receive either durvalumab + FLOT or placebo + FLOT, the study revealed improved pathologic complete response (pCR) rates with durvalumab + FLOT across regions. Despite baseline variations, the addition of durvalumab consistently enhanced pCR compared to placebo. Ongoing for event-free survival, MATTERHORN suggests the potential of durvalumab + FLOT in GC/GEJC treatment. This interview took place at the 2024 ASCO Gastrointestinal (GI) Cancers Symposium in San Francisco, CA.

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