Georgina Long, MD, PhD, FRACP, University of Sydney, Sydney, Australia, talks to us about the ongoing POLARIS trial (NCT03911869). The trial aims to investigate how encorafenib, a BRAF inhibitor, combined with the MEK inhibitor binimetinib interacts in the brain of patients with advanced melanoma and active brain metastasis. This interview took place at the European Society for Medical Oncology (ESMO) 2019 congress in Barcelona, Spain.