Olivia Rongze Lu, PhD, University of Texas at Austin and Dell Medical School, Austin, TX, outlines the main mitochondrial pathways affected in cancer cells and highlights recent studies exploring novel molecules targeting mitochondrial metabolic processes such as oxidative phosphorylation, mitochondrial membrane potential and mitochondrial dynamics for the treatment of glioblastoma. This interview took place during the 36th Society for Immunotherapy of Cancer (SITC) Annual Meeting in Washington, D.C.