Maria Concetta Fargnoli, MD of University of L’Aquila, L’Aquila, Italy, discusses genetic testing for skin cancer in clinical practice. First, Dr Fargnoli highlights the review of all the important melanoma susceptibility genes identified to date, focusing on the main gene that can be screened in daily practice. She highlights that some genes are very rarely mutated, and their real utility in clinical practice is limited. Therefore, Dr Fargnoli has so far reviewed the most important genes; two genes that have been identified 20 years ago, and additional genes that have been identified as a result of next-generation sequencing (NGS) techniques developed quite recently. According to Dr Fargnoli, more research and data on the clinical utilities of these genes is to be expected. Recorded at the 2016 World Congress on Cancers of the Skin (WCCS) and the Congress of the European Association of Dermato-Oncology (EADO) in Vienna, Austria.