Anna Diana, MD, University of Campania Luigi Vanvitelli, Naples, Italy and UOC Oncologia, Ospedale del Mare, Naples, Italy, discusses efficacy of the triple combination of estrogen receptor (ER), CDK4/6 and PI3K pathway inhibitors in ex-vivo models of breast cancer. Results showed an encouraging activity of the triple combination of ER, CDK4/6, and PI3K pathway inhibitors in ex vivo models of ER-positive breast cancer. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).