Anil Kapoor, MD, FRCSC, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada, outlines the importance of careful patient selection for cytoreductive nephrectomy, referencing the CARMENA trial (NCT00930033), which tests the benefit of nephrectomy compared to sunitinib. This interview took place at the 2020 Genitourinary Cancers Symposium, held in San Francisco, CA.