Joaquin Mateo, MD, from the The Institute of Cancer Research & The Royal Marsden, London, UK talks to us about the treatment of metastatic prostate cancer patients. Dr Mateo explains the current methods used and tells us what is the most significant problem facing experts in the field. He also talks about his focus on uncovering the genomic landscape of prostate cancer and highlighting the most commonly aberrated genes, describing how this work will be applied in the future. This interview was recorded at the 2017 European Society for Medical Oncology (ESMO) conference held in Madrid, Spain.