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ESMO 2025 | Evaluating toxicity from enzalutamide in the ENZARAD trial

Paul Nguyen, MD, MBA, Dana-Farber Cancer Institute, Boston, MA, highlights the patient-reported quality of life in the ENZARAD trial (NCT02446444), noting that while there were more reported toxicities such as fatigue and neurological side effects, there were no differences in cardiac issues or seizures with enzalutamide. The quality of life differences to be largely as expected with enzalutamide. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

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Transcript

That’s a great question. We have a lot more to do in terms of understanding the patient-reported quality of life. I mean, in terms of just the reported toxicities, we did see more fatigue as expected. We saw more, especially grade one, grade two, neurological side effects. We saw some more hypertension. But reassuringly, there was no difference in cardiac and no difference in seizures for enzalutamide, which I know people have been worried about...

That’s a great question. We have a lot more to do in terms of understanding the patient-reported quality of life. I mean, in terms of just the reported toxicities, we did see more fatigue as expected. We saw more, especially grade one, grade two, neurological side effects. We saw some more hypertension. But reassuringly, there was no difference in cardiac and no difference in seizures for enzalutamide, which I know people have been worried about. So, you know, I think overall the quality of life differences were probably as one would expect with enzalutamide, but we’re going to delve into that more deeply.

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