The occurrence of immune-related side effects is characteristic of immunotherapy to treat cancer. Paolo Ascierto, MD from the National Tumour Institute Fondazione G. Pascale, Naples, Italy discusses the importance of managing these symptoms, explaining why early detection and the use of immunosuppressive agents is so vital. He also talks about why education on this topic is needed, both for patients and healthcare professionals, and how this could be accomplished. This interview was recorded at the 2017 European Society for Medical Oncology (ESMO) conference held in Madrid, Spain.