Laura J. van ‘t Veer, PhD, University of California San Francisco, San Francisco, CA, discusses the upcoming approaches in breast cancer evaluated at the San Antonio Breast Cancer Symposium (SABCS) 2020, including the results of the I-SPY SURMOUNT study (NCT01042379) and the importance of evaluating the biology of disease to inform treatment choices. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).