ESMO WCGIC 2023 | Elucidating the optimal total neoadjuvant therapy in rectal cancer

Lucjan Wyrwicz, MD, PhD, Maria Sklodowska-Curie National Cancer Research Institute, Warsaw, Poland, comments on the latest developments in total neoadjuvant therapy for patients with rectal cancer. Trials including the Polish II study (NCT00833131) have demonstrated the benefits of total neoadjuvant therapy in terms of limiting metastasis, but improvements in local disease control have yet to be seen. Further real-world studies are additionally needed to assess whether short course or long course radiotherapy is superior, and international cohorts will be pivotal to make this possible. This interview took place at the ESMO World Congress on Gastrointestinal Cancer (WCGIC) 2023 in Barcelona, Spain.

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