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GU Cancers 2023 | TRITON3 interim OS results demonstrate superiority of rucaparib over docetaxel for mCRPC

Alan Haruo Bryce, MD, Mayo Clinic, Rochester, MN, reports on the interim overall-survival (OS) results of the Phase III TRITON3 (NCT02975934) trial assessing rucaparib versus physician’s choice in patients with chemotherapy-naïve metastatic castration resistant prostate cancer (mCRPC) with BRCA1/2 (BRCA) or ATM alterations. The primary endpoint was radiographic progression-free survival (rPFS) first tested in the BRCA subgroup, then the intent-to-treat (ITT) population and OS was a key secondary endpoint. 302 pts with BRCA and 103 pts with ATM alterations were randomized. OS maturity was 54% in the BRCA subgroup and 59% in the ITT population. The results were positive, demonstrating the superiority of rucaparib over physician’s choice. This interview took place at the ASCO GU Cancers Symposium 2023 in San Francisco, CA.

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