SABCS 2023 | Tumor immune architecture in TNBC

Saranya Chumsri, MD, Mayo Clinic, Jacksonville, FL, highlights data of a Phase III trial (NCT00114816) evaluating the outcomes and characteristics of patients with triple-negative breast cancer (TNBC) with one of three immune landscape architectures based on the locations of stromal tumor-infiltrating lymphocytes (sTILs) – namely immune enriched (IN), immune excluded (IE), and immune desert (ID). The study showed that patients with IE tumors had poor outcomes despite having high TILs, and a more in-depth analysis noted the central role of plasmacytoid dendritic cells and IFN-alpha in TNBC. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) congress in San Antonio, TX.

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