The global prevalence of CLDN18.2, a biomarker associated with gastric or gastroesophageal junction (G/GEJ) adenocarcinoma, was investigated in two Phase III studies of zolbetuximab, namely SPOTLIGHT (NCT03504397) and GLOW (NCT03653507). These studies focused on patients with locally advanced unresectable or metastatic G/GEJ adenocarcinoma. In this interview, Kohei Shitara, MD, National Cancer Center Hospital East, Kashiwa, Japan, discusses the findings of a biomarker analysis aimed to determine the frequency of CLDN18.2 expression in this patient population. Understanding the prevalence of CLDN18.2 can provide valuable insights into the potential use of zolbetuximab, a monoclonal antibody that targets CLDN18.2, as a therapeutic option in these patients. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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