Bishal Gyawali, MD, PhD, Queen’s University, Kingston, ON, Canada, discusses the flaws in clinical trial designs that can skew the European Society of Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS). The ESMO-MCBS is a standardized, validated tool to assess the clinical benefit from anticancer therapies in clinical trials. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).