Barbara Pistilli, MD, Institut Gustave Roussy, Villejuif, France, discusses the contradiction between the results of PALLAS (NCT02513394) and MONARCH 3 (NCT02246621) clinical trials. An explanation for the difference could be the more advanced stages of breast cancer involved in MONARCH 3. An analysis is still ongoing to clarify the contradiction in results. Dr Pistilli also discusses the promising results of the SOLAR-1 (NCT02437318) trial which has shown clinical significance. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).