Qing Zhou, MD, PhD, Guangdong Lung Cancer Institute, Guangzhou, China, describes her presentation at the World Conference on Lung Cancer (WCLC) 2021, which provides an overview of emerging first-line treatment strategies in extensive-stage small cell lung cancer (ES-SCLC). Current standard of care for ES-SCLC is chemotherapy plus PD-L1 immunotherapy, however there are currently no definitive biomarkers to predict the benefit of immunotherapy. Dr Zhou highlights translational work that sought to define four molecular subtypes of SCLC, as well as the promise of large, ongoing biomarker-driven clinical trials that could impact clinical practice in the future. This interview took place at the WCLC 2021.