Toni Choueiri, MD, Dana Farber Cancer Institute, Boston, MA, discusses whether liquid biopsy could replace traditional risk factors in renal cell carcinoma (RCC). A big challenge for the diagnosis of RCC is detecting the low level of ctDNA, for which liquid biopsy is a promising possible solution. This interview took place at the International Society of Liquid Biopsy (ISLB) 2021 Virtual Meeting.