Sebastian Kobold, MD, PhD, Ludwig-Maximilians-Universität München, Munich, Germany, discusses key issues faced when applying cellular therapies to solid tumors including access to tumor tissue, T-cell engagement and heterogeneity of antigen expression. To mitigate these challenges, modular platforms can be used to selectively target cancer cells to allow control over T-cell activity and to target multiple antigens simultaneously with a single T-cell. This interview took place at the Immunotherapy of Cancer (ITOC) Conference 2022 in Munich, Germany.
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