Heather McArthur, MD, MPH, UT Southwestern Medical Center, Dallas, TX, comments on unanswered questions relating to the sequential use of antibody-drug conjugates (ADCs) in patients with breast cancer. Additional prospective research is needed to assess the utility of administering ADCs with varying payloads such as trastuzumab emtansine after trastuzumab deruxtecan, a TOPO1 inhibitor. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) congress in San Antonio, TX.
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