Alexandra Drakaki, MD, PhD, University of California Los Angeles, Los Angeles, CA, comments on the Phase III NIAGARA trial (NCT03732677), the first neoadjuvant study combining durvalumab with standard chemotherapy (cisplatin-gemcitabine) for cisplatin-eligible patients with muscle-invasive bladder cancer (MIBC). This groundbreaking trial explores the use of immunotherapy alongside chemotherapy prior to surgery, followed by a year of single-agent immunotherapy post-operatively. The findings are expected to significantly influence surgical outcomes and overall survival (OS), marking a pivotal change in clinical practice for bladder cancer treatment. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain.
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