ESMO 2024 | PATCH: transdermal estradiol versus LH-RH analogues in prostate cancer

Duncan Gilbert • 16 Sep 2024

ESMO 2024

Duncan Gilbert, MA, MRCP, FRCR, PhD, University College London, London, UK, comments on findings from the PATCH trial (ISRCTN70406718) of transdermal estradiol for androgen suppression in prostate cancer. Prior results showed that transdermal estradiol achieved sufficient testosterone suppression, improved bone density, and enhanced quality of life by reducing hot flushes, although gynecomastia was reported in some patients. Transdermal estradiol was additionally found to be non-inferior to LH-RH analogues in terms of metastasis-free survival. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain.

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