What is the case for ctDNA? We have been looking not only in tumor tissue and actual alterations within the tumor tissue, but also in ctDNA. In most cases, at least in our clinic, and I think in most clinics in Germany, probably also in other countries, tumor tissue is mostly used and not so much ctDNA. But we had like an 84% concordance, which is pretty promising, I would say because it’s so much easier to just draw blood...
What is the case for ctDNA? We have been looking not only in tumor tissue and actual alterations within the tumor tissue, but also in ctDNA. In most cases, at least in our clinic, and I think in most clinics in Germany, probably also in other countries, tumor tissue is mostly used and not so much ctDNA. But we had like an 84% concordance, which is pretty promising, I would say because it’s so much easier to just draw blood. There was another talk in the same session and that indicated that there’s also CHIP-like clonal hematopoiesis which gets more common in elderly populations so we might also find some HRR mutations that come from CHIP. So I think there are some challenges with ctDNA as well because we have to figure out if that’s from the tumor or if that’s not from the tumor.
