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ESMO Gynae 2025 | Assessing ctDNA to detect mutations in ovarian cancer in the RAMP 201 trial

Alberto Farolfi, MD, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST), Dino Amadori, Meldola, Italy, describes the limitations of circulating DNA (ctDNA) evaluation in cervical cancer. ctDNA evaluation did not correlate with molecular analysis on tissue in the RAMP 201 trial (NCT04625270), which may have been useful for patients. This interview took place at 2025 European Society for Medical Oncology (ESMO) Gynaecological Cancers Congress in Vienna, Austria.

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Transcript

Very interesting data were presented on the use of circulating DNA evaluation in a very rare disease. I mean, in the RAMP 201 trial, we saw that the evaluation of ctDNA did not correlate with the molecular analysis on the tissue. And this was very, very, I mean, it was just a pity because I believe that maybe it would be useful for our patients. Also, there was presented some interesting data on the ADCs, mainly sacituzumab, with the increased risk of cataract due to the use of the steroids to prevent the toxicity of this kind of drugs...

Very interesting data were presented on the use of circulating DNA evaluation in a very rare disease. I mean, in the RAMP 201 trial, we saw that the evaluation of ctDNA did not correlate with the molecular analysis on the tissue. And this was very, very, I mean, it was just a pity because I believe that maybe it would be useful for our patients. Also, there was presented some interesting data on the ADCs, mainly sacituzumab, with the increased risk of cataract due to the use of the steroids to prevent the toxicity of this kind of drugs. So it was quite interesting as a congress.

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Disclosures

Financial Interests, Personal, Invited Speaker: AstraZeneca, GSK-Tesaro, MSD; Financial Interests, Personal, Advisory Board: Janssen, AstraZeneca, GSK.