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ESMO 2025 | Optimizing outcomes in patients with renal cancer and bone metastases

Camillo Porta, MD, A. Moro University of Bari, Bari, Italy, comments on the negative prognostic impact of bone metastases in patients with renal cancer. Patients with bone metastases have lower progression-free survival and overall survival compared to those without, and bone metastases can lead to skeletal-related adverse events, such as pathologic fractures, pain, and hypercalcemia, which often require surgical intervention or radiotherapy. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

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Transcript

It is well known that bone metastases have a prognostic impact, a negative prognostic impact in cancer patients as a whole and also in kidney cancer and indeed in our study we were able to confirm this finding and indeed progression through survival was lower in patients with bone metastases compared to patients with without bone metastases and the same occurred for overall survival, of course...

It is well known that bone metastases have a prognostic impact, a negative prognostic impact in cancer patients as a whole and also in kidney cancer and indeed in our study we were able to confirm this finding and indeed progression through survival was lower in patients with bone metastases compared to patients with without bone metastases and the same occurred for overall survival, of course. The problem with bone metastases compared to patients without bone metastases. And the same occurred for overall survival, of course. The problem with bone metastases is that they can induce the so-called skeletal-related adverse events, which are basically represented by pathologic fractures, pain, hypercalcemia, leading to the need for surgical intervention to stabilize the bone or to radiation therapy to palliate pain.

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