Educational content on VJOncology is intended for healthcare professionals only. By visiting this website and accessing this information you confirm that you are a healthcare professional.

Share this video  

ESMO 2025 | What are the current and emerging biomarkers in urothelial carcinoma?

Sara Coca Membribes, MD, Barts Health NHS Trust, London, UK, discusses the current state of biomarkers in urothelial carcinoma, highlighting key biomarkers: FGFR, with erdafitinib showing robust data from the THOR trial (NCT03390504), HER2 for trastuzumab deruxtecan, and ctDNA. These biomarkers, including FGFR3, correlate with treatment response and have shown potential in various trials. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Transcript

So in urothelial carcinoma we have at the moment, I mean we’ve done a huge effort trying to find biomarkers in urothelial carcinoma. Right now we have four important biomarkers. We have FGFR for the first time, erdafitinib. This is probably the most robust data that we have from the THOR trial. We have erdafitinib approved by both the FDA and the EMA. And we know that FGFR3 is a mutation that correlates with treatment response...

So in urothelial carcinoma we have at the moment, I mean we’ve done a huge effort trying to find biomarkers in urothelial carcinoma. Right now we have four important biomarkers. We have FGFR for the first time, erdafitinib. This is probably the most robust data that we have from the THOR trial. We have erdafitinib approved by both the FDA and the EMA. And we know that FGFR3 is a mutation that correlates with treatment response. So we know that for sure. We have heard too. There are some data presented at this meeting about the DV combination in the first line, which is really exciting. I want to hear the data. And we also have HER2 for Trastuzumab deruxtecan. So HER2 is also, we have some robust data. We have ctDNA. And for ctDNA we have the results from the Invictus and Ignite 11, which is going to be presented on Monday, I think. It’s also very promising. And finally, these three are the most important ones.

This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.

Read more...